abstract |
and pharmaceutically acceptable salts thereof possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, X is hydrogen or -S(O)m-R<1> and Y is hydrogen or S(O)n-R<2>, except that X and Y are not both hydrogen, or one of X and Y is -S-alkyl-SH and the other is hydrogen; Z is R is hydrogen, alkyl, cycloalkyl, aryl, or aralkyl; R<1> and R<2> are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkaryl, cycloalkyl, alkoxycarbonylalkylene, any of which is optionally substituted with 1, 2 or 3 hydroxy or halo groups (e.g., wherein R<1> and/or R<2> is trifluoromethyl) or R<1> and R<2> together are alkylene (i.e., forming a ring comprising the S(O)n and S(O)m groups and the carbon atom to which they are attached) of 1 to 6 carbon atoms; R<3> is hydrogen, alkyl, ammonium, alkyl-ammonium, or alkali metal (such as Na, Li, or K); A1 and A2 are each independently hydrogen, alkyl, aryl, aralkyl, or alkaryl; m is 0, 1, or 2; and n is 0, 1, or 2. |