| abstract |
The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- wherein R<1> includes hydrogen, amino and alkyl or alkoxy each of up to 4 carbon atoms; R<2> includes hydrogen, alkyl, hydroxyalkyl and halogenoalkyl each of up to 4 carbon atoms; R<3> is hydrogen or alkyl or up to 3 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula -CO.NH-, -NH.CO-, -CO.NR<4>-, -NR<4>.CO-, -CH=CH- or -CO.O-, wherein R<4> is alkyl of up to 4 carbon atoms; and Y is a branched alkyl group bearing substituents Y<2> and Y<3> the definition of each independently including hydroxy, cyano, aryl and heteroaryl, and the definition of Y<3> also optionally including sulpho, N-phenylsulphonylcarbamoyl and 5-tetrazolyl; or a pharmaceutically-acceptable salt thereof. |