| abstract |
An isochromane derivative having the general formula I in which each of R1, R2, and R3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or represents a methylenedioxy group; R4 is selected from hydrogen or alkyl (1-4 C); Alk is an alkylene group with 1-4 carbon atoms; Alk' is an alkylene group with 2-4 carbon atoms, when R5 is selected from hydrogen or alkyl (1-4 C) and X is O or S; or Alk' is an alkylene group with 1-4 carbon atoms or a bond, when R5 is an alkyl (1-4 C) group and X is CH2 or a bond; or a pharmaceutically acceptable salt thereof. |