http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-902829-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10120566446f99cb28c6391b74e184cf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 1990-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1991-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-902829-A1 |
| titleOfInvention | Microencapsulated taste-masked water-insoluble nsaid drug¹materials |
| abstract | This disclosure is directed to preparation of individual taste-masked, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantial absence of microcapsule agglomerates. These taste-masked microcapsules contain a high payload, e.g. at least 83+ wt.% of said NSAID drug material and can then be formulated into chewable tablets and liquid aqueous suspensions for medicinal use. Cellulose acetate phthalate is the micro-encapsulating polymer wall material. Control of pH, controlled addition of a Hofmeister (lyotropic), salt, microencapsulation of the water-insoluble NSAID medicament with a liquid phase of cellulose acetate phthalate microencapsulating material and the subsequent insolubilization of said liquid encapsulating material after it is wrapped around the medicament core with dilute acid are important process parameters to achieving the proper individual microcapsules to obtain taste-masked, water insoluble NSAID drug materials, esp., naproxen and ibuprofen, by microencapsulation alone. |
| priorityDate | 1989-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.