| abstract |
A compound of the formula <CHEM> and when appropriate in the form of a racemic mixture or in the form of a stereoisomeric component and the pharmaceutically acceptable salts thereof, in which formula n is an integer 0,1 or 2 Y is [CH2]m, CHOH, CHOCH3, CHNHR or CHF, m is an integer 0 or 1 and R is hydrogen, methyl or ethyl, Z is hydrogen or a saturated or unsaturated, straight or branched alkyl group containing 1-3 carbon atoms, A is a group <CHEM> wherein Ra is a straight or branched hydroxyalkyl or an alkyl group containing 1-5 carbon atoms and optionally substituted by one or more fluoro atoms, Rc is a saturated or unsaturated, straight or branched alkyl group containing 1-4 carbon atoms and optionally substituted by one or more fluoro atoms, Ra min is the same as Ra and independently of Raa sec , Ra sec is the same as Ra and independently of Ra min , p is an integer 0, 1 or 2, s is an integer 2, 3, 4, 5 useful for the treatment of cardiac arrhythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation of such compounds as well as intermediates for their preparation.n[EP0322390A2] |