| abstract |
There are disclosed compounds of the formula <CHEM> wherein A is alkyl of 3-19 carbon atoms, diloweralkylvinyl, dihalovinyl, diphenylvinyl, lower alkynyl <CHEM> X is N or CR; Z is - @=@-, - @=N-, -N= @-, -@-, S or O; R is hydrogen or lower alkyl; R<1> is hydrogen, lower alkyl or phenyl; R<2> is hydrogen or lower alkyl; or R<1> and R<2> taken together with the carbon atoms to which they are attached form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions and as cyloprotective agents. Intermediates for these compounds are also disclosed.n[EP0301813A1] |