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filingDate 1984-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1984-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IE-840311-L
titleOfInvention D-homo-steroids
abstract The novel D-homosteroids of the formula <IMAGE> I wherein R1 represents a -CN, =NOH or =CH-NHOH group; R2 represents oxo or, where R1 represents a -CN group, R2 represents oxo or a -OAc group; or R1 and R2 together with carbon atoms 2 and 3 of the steroid skeleton represents a [2,3-d]-fused isoxazole ring, a [3,2-c]-fused pyrazole ring, a [3,2-c]-fused N-acylated pyrazole ring or a [2,3-c]-fused furazan ring; Ac represents an acyl group; R3 and R4 represent methyl and R5 and R6 together represent an additional bond between carbon atoms 5 and 6 of the steroid skeleton; or R4 and R5 together represent -O-, R3 represents hydrogen or methyl, and R6 represents hydrogen; R7 represents hydrogen, lower-alkyl or ethynyl; R8 represents hydroxy or acyloxy; or R7 and R8 together represent a spiroether group of the formula <IMAGE> 17a or a spirolactone group of the formula <IMAGE> 17a the dotted 16,17-bond is an optional additional carbon-carbon bond; and the dotted 2,3-bond is an additional carbon-carbon bond when R1 and R2 together with carbon atoms 2 and 3 form the isoxazole or pyrazole ring or when R2 represents a -OAc group, inhibit the synthesis of progesterone in organisms and can be used for fertility control. The novel D-homosteroids can be manufactured by molecular modifications of other D-homosteroids.n[US4578475A]
priorityDate 1983-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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