| abstract |
1-Phenyl-3-azabicyclo[3.1.0]hexane-2,4-diones of the formula <IMAGE> (I) wherein R1 is hydrogen, R2 is hydrogen, sulfo or acyl and R3 is hydrogen, or R1 is a saturated or unsaturated aliphatic, cycloaliphatic or cycloaliphatic-aliphatic carbon radical of up to and including 18, preferably of up to and including 12, carbon atoms, R2 is hydrogen, lower alkyl, sulfo or acyl and R3 is hydrogen or lower alkyl, and to salts thereof, and salts thereof, have valuable pharmacological properties and are effective aromatase inhibitors. They can therefore be used for the treatment of hormonal diseases, in particular mammary carcinomas.n[US4839379A] |