| abstract |
Compounds of the formula <CHEM> where R is hydrogen, methyl, ethyl, propyl, 2-propenyl or 2-propynyl; an R min is hydrogen or fluoro possess glucocorticoid activity. The compounds where R is H are prepared by reacting a compound of the formula <CHEM> with (1H, 3H)-pyrimidine-2,4,5,6-tetrone, The compounds where R is other than hydrogen are prepared by reacting a compound where R is hydrogen with the appropriate alkylating agent.n[EP0058841A2] |