| abstract |
Compounds of formula (I): <IMAGE> (I) wherein: X is CH2, O, S or NR wherein R is hydrogen or C1-4 alkyl; Y and Z are independently selected from hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R1 is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-4 alkyl any of which phenyl moieties may be substituted by one or more of C1-6 alkyl, C1-6 alkoxy, halogen or CF3; R2 is hydrogen, OH, C1-6 alkoxy, phenyl-C1-4 alkoxy, C1-7 acyloxy or NR4R5 wherein R4 and R5 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen and R5 is OH or C1-4 alkoxy; or R4 and R5 together form C3-6 polymethylene optionally interrupted by O or NR6 where R6 is hydrogen or C1-4 alkyl; or together with R1 forms an oxo group or =NOR7 wherein R7 is hydrogen or C1-6 alkyl; and R3 is hydrogen or C1-6 alkyl have useful pharmacological activity, processes for their preparation and their use.n[US4442098A] |