| abstract |
Novel pharmaceutically useful compounds of the formula <IMAGE> and pharmaceutically acceptable salts and individual optical isomers thereof, wherein Y is -CH2F, -CHF2, -CH2Cl or -CHCl2; R1 is hydrogen, (C1-4alkyl)carbonyl, (C1-4alkoxy)carbonyl or -CO-CHNH2-R27 wherein R27 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R is hydroxy, alkoxy of 1 to 8 carbon atoms, -NR7R8 wherein R7 and R8 are the same or different and are each hydrogen or alkyl of 1 to 4 carbon atoms or -NH-CHR9-COOH wherein R9 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p- hydroxybenzyl; and R2, R3, R4, R5 and R6 are various combinations of hydrogen, methyl, ethyl, tert-butyl, halogen, trifluoromethyl and OR10 wherein R10 is hydrogen, alkyl of 1 to 8 carbon atoms, (C1-6alkyl)carbonyl, benzoyl or phenyl (C1-6alkyl)-carbonyl or R3 and R4 together are methylenedioxy.n[GB2005659A] |