| abstract |
The present invention is concerned with novel 11-methylene-oestr-15-enes of the formula: wherein R1 = H or acyl with 1-18 C-atoms, preferably H, R2 = ethinyl, vinyl, chloroethinyl, allyl or propinyl; ethinyl being preferred, and R3 = O or H2, preferably O. Further the present invention is concerned with processes for the preparation of the above compounds and with pharmaceutical compositions comprising these compounds. The compounds possess powerful gestagenic properties and only slight androgenic side-effects. |