http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-58304-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4209078d025bee83bc1ad02a70fcf2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 1985-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-58304-B1 |
| titleOfInvention | Quinoline derivatives |
| abstract | The invention relates to new quinoline derivatives of the formula: I wherein R stands for C2H5, C2H4F, CH2-O-CH2-CH2OH, +TR to a process for their preparation comprising reacting, for 12-24 hours, at 70 DEG -95 DEG C., in dimethylformamide, the 1,4-dihydro- 3-ethoxycarbonyl- 6,8- difluoro-4-oxo-quinoline with an excess of RX (2-5 mol of RX for one mol of quinoline), in the presence of K2CO3 and subsequently hydrolyzing the obtained 3-ester by HCl under reflux conditions and to pharmaceutical compositions comprising at least one 1,4-dihydro- 3-carboxy- 6,8-difluoro- 1-R-4-oxo-quinoline derivative in admixture with a pharmaceutically acceptable diluent or carrier. |
| priorityDate | 1984-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.