| abstract |
Novel pharmaceutically useful derivatives of selected known bio-affecting carboxylic acids and a process for preparing them are disclosed, said derivatives having the structural formula wherein R,, R2, X and X' are e.g. hydrogen, or C1-C5 alkyl; and R-COO- is the acyloxy residue of: n(a) a monocarboxylic acid, e.g. indomethacin;n(b) a steroidal monocarboxylic acid;n(c) a cephalosporin antibiotic having one carboxylic acid function;n(d) a penicillin antibiotic having one carboxylic acid function; orn(e) y-aminobutyric acid, captopril or valproic acid; or having the structural formulawherein -OOC-R'-COO- is the di(acyloxy) residue of:n(a) A cephalosporin antibiotic having two carboxylic acid functions;n(b) a penicillin antibiotic having two carboxylic acid functions; orn(c) the dicarboxylic acid, methotrexate.nNon-toxic pharmaceutically acceptable acid addition salts, N-oxides and quaternary ammonium salts of the compounds of formulas (I) and (II) are also disclosed. |