| abstract |
Compounds of the formula:- where nR1 is hydrogen, C1-C4 alkyl, C3-C7 cycloalkyl or phenyl;nR2 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, or halo;nR3 is hydrogen or C1-C4 alkyl;nX is-(CH2)n- where n is 1, 2 or 3, -CH2CH(CH3)- or -CH2 nY is -COOH, -COO (C1-C4 alkyl, -CONH2, -CN or 5-tetrazolyl; andnZ is 3- or 4-pyridyl;nand the pharmaceutically acceptable salts thereof. The compounds selectively inhibit the action of the thromboxane synthetase enzyme and may thus be useful in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, cancer and the vascular complications of diabetes. |