| abstract |
Imidazoles of the formula: …… wherein R<1> is lower cycloalkyl, lower cycloalkyl-lower alkyl, lower alkenyl-lower alkyl, lower alkanoyl, phenyl, lower cycloalkyl-carbonyl, or a group of the formula: …… wherein X is hydrogen, carboxy or lower alkoxycarbonyl; Y is hydrogen, lower alkyl, lower alkoxy or halogen; n is an integer of from 1 to 4; and Z is cyano, carboxy or lower alkoxycarbonyl; and the pharmaceutically acceptable acid addition salts thereof. The compounds selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclooxygenase enzymes and are thus useful in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine and the vascular complications of diabetes. |