http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-48101-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 |
| filingDate | 1978-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1984-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-48101-B1 |
| titleOfInvention | Process for the acylation of 7-aminocephem derivatives |
| abstract | 1. A process for the acylation of 7-amino-cephem derivatives, which comprises converting an acylating component of the formula I see diagramm : EP0002774,P20,F1 in which R**1 is alkyl having from 1 to 4 carbon atoms, phenyl, 2-furyl or thiazolyl of the formula see diagramm : EP0002774,P20,F2 in which R4 is hydroxy, amino, alkenylamino having from 2 to 4 carbon atoms, formamino or acetamino optionally substituted by chlorine, bromine, fluorine, phenoxy or by 1,3,4-thiadiazolylthio in turn substituted by methyl or amino ; R5 is hydrogen, halogen, cyano, thiocyano, hydroxy or alkoxycarbonyl having from 1 to 4 carbon atoms in the alkyl moiety ; R**2 and R**3 together are oxygen or a group of the formula VIII =N-X which preferably has the syn configuration, and in which X is hydroxy, alkoxy having from 1 to 4 carbon atoms, benzyloxy, p-chlorobenzyloxy, triphenylmethoxy, aminocarbonylmethoxy, tert-butoxycarbonylmethoxy, methoxycarbonylmethoxy, ethoxycarbonylmethoxy, cyanomethoxy, allyloxy, bromallyl-oxy, phenoxy or acyloxy having from 1 to 4 carbon atoms ; with a 1-hydroxybenzotriazole of the general formula II see diagramm : EP0002774,P20,F3 in which R**6 through R**9, being identical or different, each are hydrogen, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, halogen, cyano, nitro, aminocarboxy, alkylaminocarboxy having from 1 to 4 carbon atoms in the alkyl moiety, aminosulfonyl, alkylaminosulfonyl having from 1 to 4 carbon atoms in the alkyl moiety, dialkylaminosulfonyl having from 1 to 4 carbon atoms in the alkyl moiety ; to an active derivative, and subsequently reacting the latter one with a 7-aminocephem derivative. |
| priorityDate | 1977-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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