| abstract |
Novel substituted (3-loweralkylamino-2-R1O-propoxy) pyridines, their pharmaceutically acceptable salts and formula wherein n is 3, 4, 5 or 6, R is C3-C4 branched alkyl, R1 is H or -@-L wherein L is selected from C1-C10 alkyl, phenyl and substituted phenyl having up to two substituents which are independently selected from C1-C4 alkyl, C1-C4 alkoxy and halo, R2 is F, CN, CF3, Cl, , NO2, -COOR5 wherein R5 is H, C1-C6 alkyl or C6-C12 carbocyclic aryl, -CONR6R7 wherein R6 and R7 when separate, are H or C1-C6 alkyl and when joined, are -CH2-(CH2)3-CH2-, -CH2-CH2-O-CH2-CH2, -CH2-CH2-NH-CH2-CH2- or -CH2- CH2-N(CH3)-CH2-CH2-, and R3 and R4 are independently selected from H, C1-C4 alkyl, CF3, F, C1-C4alkyl-@-NH, phenyl and substituted phenyl wherein said substituents are independently selected from C1- C4alkyl, C1-C4alkoxy and halo, such that one of R3 and R4 is other than H, and pharmaceutically acceptable salts thereof, and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as beta -adrenergic blocking activity. |