| abstract |
Prostane derivatives of the formula I wherein R1 is OR2 or NHR3; R2 is hydrogen, C1-10 alkyl, C4-10 cycloalkyl, C6-10 aryl, or a 5 or 6 membered heterocyclic ring having 1-3 hetero atoms selected from O, N and S; R3 is the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms; W is (a) an OH-substituted methylene group, (b) a wherein the OH-groups in (a) or (b) can be in the alpha - or beta -position, or (c) such a group wherein the H atom of the OH group is replaced by the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms or by a conventional etherifying OH-blocking group; R4 is OH or hydroxy whose H atom is replaced as defined for W; and R5, R6, R7, R8, R9, R10 and R11 each independently is hydrogen or alkyl of 1-5 carbon atoms; or R9 and R10 together represent a direct bond; and, when R11 is alkyl, R10 can also be chlorine; and, for a derivative wherein R2 is hydrogen, the salts thereof with physiologically compatible bases, have improved prostaglandin activity. |