| abstract |
There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, <IMAGE> I in which R1 represents hydrogen, hydroxy or -NR5R6, in which R5 and R6, which may be the same or different, each represent hydrogen or alkyl C 1 to 6, AN ADJACENT PAIR OF R2, R3 and R4 form a -(CH2)4- chain, and the remaining substituent R2 or R4 represents alkyl C 1 to 9, E represents a 5-(IH)tetrazolyl- or a -COOH group, and X represents oxygen or a group -NR7- in which R7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof.n[US4160844A] |