http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-45148-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e6c80a50846f752716f524cff4632c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-56 |
| filingDate | 1977-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1982-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-45148-B1 |
| titleOfInvention | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
| abstract | 1495488 Optically active 2 - (2 - phenyl- 5-benzoxazolyl)propionic acids IPPCO INTERNATIONAL PHARMACEUTICAL PATENTS CO ESTABLISHMENT 23 June 1976 26096/76 Heading C2C Novel optically active compounds of the Formula I in which X is F or Cl and therapeutically acceptable salts with bases, may be prepared by the sucessive steps of (a) resolving 2-(4- hydroxy - 3 - nitrophenyl) - propionitrile into its optical isomers (b) reducing the nitro group of the laevorotatory isomer to (-)2-(4-hydroxy- 3 - aminophenyl)propionitrile, (c) cyclizing this product with p-fluoro or p-chloro-benzoylhalide to form the (-)2-(2-p-halophenyl-5- benzoxazolyl)-propionitrile and (b) hydrolysing the nitrile group, with an accompanying inversion of configuration. Step (a) is preferably effected via the lephedrine salt and the residual isomer is racemized and reused. Pharmaceutical compositions of the compound I with the usual excipients show antiinflammatory activity when administered orally, parenterally or rectally. |
| priorityDate | 1976-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.