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filingDate 1977-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1982-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IE-44885-B1
titleOfInvention Process for the preparation of aminoglycoside derivatives and cyclic urethane intermediates for use therein
abstract 1529243 Oxazolidinones and oxazinones PFIZER Ltd 22 Feb 1977 [25 Feb 1976] 07529/76 Heading C2C Novel oxazolidinones and oxazinones of the general Formula III wherein R4 is H or OH, R7 is H, C 1-4 alkyl or benzyl, n is 0 or 1, except that n is not O when R4 is OH, and X is O or (OH) 2 , are prepared by oxidation of the corresponding compound in which -CHX is replaced by or Aminoglycosides of the general formula wherein R is H or C 1-4 alkyl, R1 is H or methyl, R2 is OH or NH 2 , each R 3 is H or OH, one of R5 and R6 is H and the other is H or glycosyl and the broken line is an optional second bond when each R3 is H, are prepared by reacting an amine of the general formula in which one or more of the free amino groups, other than the 1-amino group, may optionally be protected, with the oxazolidinone or oxazinone (III), reducing the product to form a substituted amine of the general formula in which one or more of the primary amino groups may optionally be protected, hydrolysing the cyclic urethane group and, if necessary, removing any amino-protecting groups and optionally removing the group R7, when R7 is a benzyl group; by hydrogenation.
priorityDate 1976-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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