http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-44364-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df4e72183c5ee38a234212562dca6570 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 |
| filingDate | 1977-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1981-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-44364-B1 |
| titleOfInvention | Thienothienyl carbonyl-phenylalkanoic acids and derivatives thereof |
| abstract | 1515101 Thienothiophenes RHONEPOULENC INDUSTRIES 27 Jan 1977 [29 Jan 1976 20 July 1976 16 Dec 1976] 03379/77 Heading C2C Novel compounds I (wherein R represents a hydrogen atom or an alkyl radical, R 1 represents a hydroxy, amino, or alkoxy radical, or an alkylamino or dialkylamino group, the various alkyl radicals and the alkoxy radical being optionally substituted by a dialkylamino group, it being understood that in the definitions of R and R 1 above the alkyl radicals and the alkoxy radical contain from 1 to 4 carbon atoms and that the alkyl radicals of the dialkylamino groups may be linked together to form a heterocyclyl radical with 5 or 6 atoms in the ring which may optionally contain another hetero-atom selected from nitrogen, oxygen and sulphur, and the symbol A represents the thieno[2,3-b]thien-2-yl or thieno[3,2-b]thien-2-yl radical, the A-CO- grouping being attached to the 3- or 4-position of the phenyl ring), and salts thereof, are prepared by (a) hydrolysis of corresponding cnyao compounds, (b) decarboxylation of corresponding 5 - carboxy - 2 - thienothienylcarbonyl - phenylmethyl - carboxylic acids (themselves prepared via corresponding alkyl esters), (c) alkylation of compound I in which R is H, (d) esterification of amidification procedures, or (e) hydrolysis and decarboxylation of appropriate cyanoacetic, malonic or acetylacetic esters. The preparation of other intermediates is disclosed. Pharmaceutical compositions having analgesic, antipyretic, anti-inflammatory and platelet aggregation inhibiting activity, for oral, rectal, parental or topical administration, comprise one of the above novel compounds together with a pharmaceutical carrier. |
| priorityDate | 1976-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.