http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-43874-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdaa64756184e715af6cb25ebc318917 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-57 |
| filingDate | 1976-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1981-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-43874-B1 |
| titleOfInvention | Cephalosporin derivatives |
| abstract | 1509500 Cephalosporins YEDA RESEARCH & DEVELOPMENT CO Ltd 25 Oct 1976 [24 Oct 1975] 44185/76 Heading C2C The invention comprises novel compounds (I) wherein either Aryl is a benzene ring, Y is hydrogen, chlorine, bromine, or alkyl or nalkoxy or from 1 to 4 carbon atoms and Z is a bond, oxygen, sulfur or imino or Aryl is a thiophen ring attached to Z at its 2-position, Y is hydrogen and Z is a bond; W is hydrogen, methyl, amino, hydroxy, SO 3 H or COOR 1 wherein R 1 is hydrogen or 5-indanyl; n is zero, I or 2 with the proviso that it is not zero when W is not hydrogen or methyl and Z is not a bond; R 2 is hydrogen or methoxy; M is hydrogen, a pharmaceutically acceptable non-toxic cation, alkanoyloxymethyl as represented by the structure: wherein R 3 is alkyl of from 1 to 4 carbon atoms, alkanoylaminomethyl or alkoxycarbonylaminomethyl as represented by the structure: wherein R 4 is alkyl or alkoxy of from 1 to 4 carbon atoms and R 5 is hydrogen or n-alkyl of from 1 to 4 carbon atoms, p-(alkanoyloxy)- benzyl as represented by the structure wherein R 6 is alkyl of from 1 to 4 carbon atoms, or aminoalkanoyloxymethyl as represented by the group: wherein m is 0 to 5, each of R 7 and R 8 is hydrogen or n-alkyl of from 1 to 4 carbon atoms, and each of R 9 and R 10 is hydrogen or alkyl of from 1 to 4 carbon atoms; X is hydrogen, acetoxy, 1,3,4 - thiadiazol - 5 - ylthio; 3 - methyl - 1,2,4- thiadiazol - 5 - ylthio, tetrazol - 5 - ylthio, 1- methyltetrazol - 5 - ylthio, 2 - methyl - 1,3,4- oxadiazol - 5 - ylthio, 2 - methyl - 1,3,4- thiadiazol - 5 - ylthio or 1,2,3 - triazol - 5 - ylthio; and pharmaceutically acceptable salts thereof. They are made by interacting (a) compounds (II) and NaN 3 , (b) compounds (III) and compounds (IV) or (c) compounds (I), where X is acetoxy, and an appropriate heterocyclic thiol; W2 is H, Me, NH 2 , OH, SO 3 H or CO 2 H. The following componds are also prepared: p - chloromethylphenylacetic acid and its acid chloride, p - chloromethylphenylglycine, pchloromethylphenylmalonic acid, 5 - chloromethyl - 2 - thienylacetyl chloride, o - hydroxymethylphenylacetic acid lactone, o - bromomethylphenyl acetyl chloride and o-chloromethylp-methoxy-mandelic acid chloride. Antibacterial compositions contain (I) as active ingredient. Administration is orally or parenterally. |
| priorityDate | 1975-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 256.