http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-43847-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate | 1976-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1981-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-43847-B1 |
| titleOfInvention | N-substituted phenyl-piperidine derivatives |
| abstract | 1490048 Derivatives of 3-(3,4-dihydroxyphenyl)piperidine ROUSSEL UCLAF 17 May 1976 [16 May 1975] 20309/76 Heading C2C The invention comprises compounds of formula wherein either (a) X is H or C 2-6 acyl and R is (up to C 5 ) alkyl or alkenyl, or Ph-C 1-3 -alkyl (and acid addition salts thereof), or (b) X is Me and R is EtCO, Et, Pr, Me 2 CH, allyl or Ph(CH 2 ) 2 . Also described are analogues of (b) where R is Me or Ac. In examples, these compounds are prepared by (i) O-acylation; (ii) N-substitution; (iii) converting a dimethyl ether to a diphenol with HBr; (iv) reducing R=Ac or EtCO, to Me and Et, respectively; (v) reducing a corresponding tetrahydropyridine; (vi) reacting the compound where X=Me and R = H with CH 2 O giving an intermediate (in which presumably R = CH 2 OH) which is then reduced with sodium cyanoborohydride. Therapeutic compositions having dopaminelike and in some cases also hypotensive activity, comprise the above compounds (Ia), and may be administered orally, parenterally or rectally. |
| priorityDate | 1975-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.