http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-43833-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1976-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1981-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-43833-B1 |
| titleOfInvention | Prostenoic acid derivatives,processes for their preparatioon and compositions containing them |
| abstract | 1504219 15 - Ethynyl - 15 - hydroxy - prostaglandins ROUSSEL UCLAF 28 May 1976 [29 May 1975] 22438/76 Heading C2C Novel compounds I in which A is -CHR 1 - (where R 1 is C 1-4 alkyl) or -O- and R is H, an equivalent of an alkali or alkaline earth metal, C 1-4 alkyl or ammonium or substituted ammonium radical, m and n are 0 or an integer such that m+n is 2 to 5, with the proviso that n is not 0 when A is -O-, are prepared by treatment of a compound V in which R 2 is H or C 1-4 alkyl with an acid followed, if desired, by salification or esterification of the free base. Compounds V are obtained by reacting a compound IV (in which R 2 is not C 1-4 alkyl when A is -O-) with HC#C-Mg-Hal and for compounds where A is -O- and R is C 1-4 alkyl esterifying the compound obtained. Compounds IV are obtained by oxidation of compound III followed by hydrolysis to the free acid when A is -O- and R 2 is C 1-4 alkyl. Compounds III are obtained by reacting the corresponding 9-oxo compound with a hydroxylamine salt. Compounds I have hypotensive, smooth muscle relaxing and bronchospasmolytic activity and form with a carrier or excipient a pharmaceutical composition which may be administered orally, parenterally, rectally or topically. |
| priorityDate | 1975-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.