| abstract |
Novel substituted 7-(alpha-ureidoacetamido)cephalosporins of the following formula <IMAGE> wherein R' = H or denotes methyl and R+R1 have the meaning defined in Claim 1, are prepared by reacting a compound of the formula II <IMAGE> with furoyl isocyanate or N-(2-furoyl)-N-methylcarbamoyl chloride. The free acids of the formula I, thus obtained, are also converted to their indanyl esters, phthalidyl esters and alkanoyloxymethyl esters having 1-4 C atoms in the alkyl part and, if desired, to their pharmaceutically acceptable salts. The said cephalosporins exhibit a broad spectrum of antibiotic action against gram-positive and gram-negative microorganisms.n[GB1502342A] |