http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-41450-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ad66884a6f2a66126d492e56e09be39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08 |
| filingDate | 1975-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1980-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-41450-B1 |
| titleOfInvention | Piperazine compounds their method of preparation and therapeutic compositions containing same |
| abstract | 1470362 2,2-disubstituted piperazines KNOLL AG CHEMISCHE FABRIKEN 5 Aug 1975 [12 Aug 1974] 32633/75 Heading C2C The invention comprises compounds of formula and their salts with physiologically tolerable acids, wherein R 1 is H or Ph 2 CH (in which the pH atoms may be replaced by Cl); R 2 is H, C 1-4 acyl, C 1-8 straight chain alkyl, C 3-4 alkenyl, C 4-8 (dialkylaminoalkyl), C 2-4 hydroxyalkyl (optionally esterified with benzoic or pyridine carboxylic acids, either of which may contain C 1-4 alkoxy in the nucleus), C 2-4 carboalkoxy or EtO 2 CCH 2 ; and R 3 , R 4 are each C 1-4 alkyl. In examples, these compounds are prepared by reducing the 3-oxo analogues, or by introducing or modifying substituents on the N-atoms. Starting materials otherwise prepared are 1- benzyl-3-oxo analogues, as well as 3,4-(MeO) 2 C 6 H 3 CH 2 C(X) (Me)CO 2 Me, where X is PhCH:N-, PhCH 2 NH- or PhCH 2 N(CH 2 CN)-. Therapeutic compositions having anti-arrhythmic activity comprise compounds of the abova formula, and may be administered orally or parenterally. |
| priorityDate | 1974-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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