http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-40447-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c4cb9b5558ad97d3acc0db1113f7727 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 |
| filingDate | 1974-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1979-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-40447-B1 |
| titleOfInvention | Disubstituted azabicycloalkanes, a process for their prepation and pharmaceutical compositions containing them |
| abstract | 1458217 Disubstituted azabicycloalkanes SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 13 Dec 1974 [14 Dec 1973] 58034/73 Heading C2C Novel compounds of the Formula I in which n is 0, 1 or 2; R is a saturated or unsaturated aliphatic hydrocarbon having up to 5 carbon atoms and X 1 , X 2 , X 3 , X 4 and X 5 which are the same or different, each is hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, sulphamoyl or C 1-5 alkyl or alkoxy and acid addition salts thereof may be prepared by condensing a compound II an optionally substituted benzoyl chloride III Alternatively compounds of the Formula I in which at least one of the substituents X 1 to X 5 is amino may be prepared by condensing a compound of the Formula II with an acetylaminobenzoic acid IV in which at least one of X<SP>1</SP> 1 to X<SP>1</SP> 5 is acetylamino and the others have the meaning of X 1 to X 5 with the exception that they cannot be amino, and deacetylating the product. The starting materials I are prepared as disclosed and claimed in divisional Specification 1,458,218. 2 - Methoxy - 5 - sulphamoyl - benzoyl chloride is prepared by reacting o-anisic acid with chlorosulphonic acid to yield 2-methoxy-chloro sulphonyl benzoic acid which on reaction with ammonia yields 2-methoxy-5-sulphamoyl-benzoic acid which is converted to its acid chloride. Pharmaceutical compositions of the compounds I or a physiologically tolerable acid addition salt thereof with the usual excipients show anti-emetic, gastric evacuation stimulating, gastric antisecretory, central nervous system depressing and hypotensive activity when administered orally, parenterally or rectally.n[GB1458217A] |
| priorityDate | 1973-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.