http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-40308-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b86dbdcfe153c2dfb874aff99d07177 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-30 |
| filingDate | 1974-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1979-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-40308-B1 |
| titleOfInvention | 2-acylaminooxauoles, methods for their preparation and their use |
| abstract | 1497536 N - Alkyl - N - oxazolyl - amides LILLY INDUSTRIES Ltd 17 Dec 1974 [17 Dec 1973] 58351/73 Heading C2C Novel compounds I in which R<SP>1</SP> is C 1-6 alkyl, C 2-6 alkenyl, C 3-6 alkynyl in which the -C#C- group is not adjacent the N-atom, C 2-6 alkoxyalkyl, C 2-6 carboxyalkyl, C 1-6 haloalkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-6 alkyl, optionally substituted phenyl-C 1-6 alkyl or optionally substituted phenyl-C 1-6 alkenyl, R<SP>2</SP> is C 1-8 alkyl C 1-6 haloalkyl, C 2-6 alkenyl, C 3-10 cycloalkyl C 3-10 cycloalkyl-C 1-6 alkyl, optionally substituted phenyl, optionally substituted phenyl- C 1-6 alkyl or optionally substituted phenyl- C 2-6 alkenyl or -N(R<SP>1</SP>)-CO-R<SP>2</SP> represents a lactam ring having 5 to 7 ring atoms and in which the substituents of the phenyl moieties are selected from halogen, CF 7 , Me, MeO and NO 2 ; are prepared by acylating a compound II to introduce the R 2 -CO group, alkylating a compound IV to introduce the R<SP>1</SP> group or reacting a compound III with an #-haloacyl-halide and cyclizing the resulting compound to form the lactan. N- butyl - N - (5 - hydroxy - 4 - methyl - 2 - oxazolyl)- isobutyramide is prepared by oxidation of the 5-unsubstituted compound using m-chloroperberzoic acid. N - Butyl - N - (4 - carboxy- 2 - oxazolyl) - isobutyramide is prepared by oxidation of 4-formyl derivative which is prepared by oxidation of 4-hydroxymethyl compound. N - (3 - Carboxypropyl) - N - (4 - methyl- 2 - oxazolyl) - isobutyramide and octanamide are prepared by hydrolysis of the ethyl ester. Compounds II (R<SP>3</SP> and R<SP>4</SP> are hydrogen, C 1-4 alkyl (or C 1-4 hydroxyalkyl) are prepared by reacting a compound R<SP>4</SP>-CH(OH)-CO-R<SP>3</SP> with an R<SP>1</SP>-substituted cyanamide; by using cyanamide the corresponding 2-amino compound is prepared and this is acylated to introduce the R 2 -CO group. Compounds I are active against hypersensitivity diseases and form with a carrier a pharmaceutical composition which may be administered orally, parenterally, rectally or topically.n[GB1497536A] |
| priorityDate | 1973-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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