| abstract |
1475177 Compositions containing indanyloxyalkanoic acid derivatives MERCK & CO Inc 7 Oct 1974 [11 Oct 1973] 43373/74 Heading A5B [Also in Divisions C2] Therapeutic compositions having diuretic activity and which are preferably administered orally comprise (1) a compound of formula including racemates and enantiomers, wherein R' is C 1-5 alkyl, C 3-5 alkenyl or alkynyl, Ph- C 1-3 -alkyl, Ph-C 3-5 -alkenyl or optionally substituted aryl or thienyl, and R is C 1-5 alkyl, cycloalkyl or optionally substituted aryl or thienyl, or CRR<SP>1</SP> form C 3-7 -ring cycloalkyl; X<SP>1</SP> is H, Me or halogen, and X<SP>2</SP> is Me or halogen, or X<SP>1</SP>-X<SP>2</SP> form a C 3-4 hydrocarbylene chain; and Y is C 1-4 alkylene or haloalkylene, together with (2) (a) 0.25-5.00 moles of a pyrazinoylguanidine compound, (b) 3.50-7.00 moles of 6-phenyl-2, 4, 7-triaminopteridine, or (c) 2.20-4.40 moles of spironolactone. (1) and (2) may be combined in the form of a salt.n[GB1475177A] |