http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-39869-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 1974-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-39869-L |
| titleOfInvention | 2- (1'-piperazinyl)- quinoxaline compounds |
| abstract | 1440722 2 - (1<SP>1</SP> - Piperazinyl) - quinoxaline compounds MERCK & CO Inc 8 July 1974 [13 July 1973 29 April 1974] 30176/74 Heading C2C Novel 2 - (1<SP>1</SP> - piperazinyl) - quinoxaline compounds of the formula in which the dotted line indicates that the compounds are saturated or ethylenically unsaturated at the 3,4-position; R<SP>1</SP> is oxygen; each of n and m is 0 or 1; R<SP>4</SP> is oxygen, hydrogen, alkyl, or aminoalkyl and R<SP>3</SP> is hydrogen, alkyl, alkoxycarbonyl, alkanoyl, aryl, substituted aryl, alkylthio, arylthio, alkoxy, amino, keto, alkylamino, dialkylamino, hydroxy, halo, carboxy, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl or alkylimino; or R<SP>4</SP> and R<SP>3</SP> are joined to form, together with the adjacent nitrogen and carbon atoms of the quinoxaline nucleus, a 5-to-7-membered ring; each of R<SP>5</SP>, R<SP>6</SP>, R<SP>7</SP> and R<SP>8</SP> is hydrogen, allyl, haloalkyl, haloalkylthio, arylalkyl, cycloalkyl, aroyl, alkyl, nitro, alkanoyl, aryl, substituted aryl, alkylthio, alkylsulphonyl, haloalkylsulphonyl, alkylsulphinyl, haloalkylsulphinyl, arylthio, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, carboxy, alkoxycarbonyl, carbamoyl, N-alkyl-carbamoyl, cyano, N,N-dialkylcarbamoyl or dialkylsulphamoyl ; R<SP>4</SP> is hydrogen, allyl, substituted allyl, haloalkyl, arylalkyl, cycloalkyl, alkanoyl, aroyl, alkylidenaminoxycarbonyl, alkoxycarbonalkylenedithiocarbonyl, alkyldithiocarbonyl, #-cyanoethyl, alkoxycarbonyl, aryloxycarbonyl, or aralkyloxycarbonyl; and each of R<SP>2</SP>', R<SP>3</SP>', R<SP>5</SP>' and R<SP>6</SP>' is keto or two of the following univalent atoms or groups: hydrogen, alkyl, alkanoyl, aryl, substituted aryl, carboxy, alkoxycarbonyl, carbamoyl, N - alkylcarbamoyl or N,N- dialkylcarbamoyl, or R<SP>2</SP>' and R<SP>3</SP>' and/or R<SP>6</SP>' and R<SP>8</SP>' are joined to form a cycloaliphatic substituent sharing the 2',3'-carbon atoms and/or 5',6'-carbon atoms, as the case may be, of the piperazine ring or a non-toxic, pharmaceutically acceptable acid-addition salt thereof, are prepared by reacting a quinoxaline of the formula with a piperazine of the formula wherein Y is a replaceable group. The novel compounds are useful as antidepressant agents in the control of appetite, sleep and pain.n[GB1440722A] |
| priorityDate | 1973-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 32.