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filingDate 1974-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1978-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IE-39553-B1
titleOfInvention Preparation of pseudodisaccharides particularly garamine and intermediates therefor
abstract Amino-protected derivatives of garamine (useful intermediates in a process for producing pseudotrisaccharide antibacterial agents such as gentamicin X2) are prepared by treating a pseudotrisaccharide having a garamine moiety glycosidically linked to another pyranoside sugar possessing vicinal hydroxyl groups (preferably vicinal trans diequatorial hydroxyl groups), said pseudotrisaccharide having amino-protecting groups (preferably carbobenzyloxy), with a glycol cleaving reagent (preferably sodium meta-periodate), treating the seco-dialdehyde derivative thereby formed with a metal borohydride, then treating the resulting seco-dihydroxy derivative with dilute aqueous acid. Typical starting compounds include the per-N-carbobenzyloxy derivatives of Antibiotic JI-20 Complex and the per-N-carbobenzyloxy derivatives of a gentamicin mixture comprising gentamicin B, gentamicin B1 and gentamicin X2.n[US3872080A]
priorityDate 1973-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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