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filingDate 1974-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1978-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IE-38730-B1
titleOfInvention Heterocyclic containing sulphoxides
abstract 1421999 Heterocyclic containing sulphoxides SMITH KLINE & FRENCH LABORATORIES Ltd 7 Feb 1974 [8 Feb 1973 23 Oct 1973] 6153/73 and 49257/73 Heading C2C Novel compounds (I) (including salts thereof) (wherein A is such that there is formed with the carbon atom shown an unsaturated heterocyclic nucleus having five or six atoms, which nucleus comprises at least one nitrogen atom and may also comprise a sulphur or an oxygen atom; X 1 and X 2 , which may be the same or different are hydrogen, alkyl, trifluoromethyl, hydroxyl, halogen, amino, or X 1 may with X 2 and at least two of the atoms comprising A form a further ring; k and m are integers from 0 to 4 provided that the sum of k and m is 3 or 4; E is oxygen, sulphur or NR 2 ; R 1 is hydrogen, alkyl, acyl or dialkylaminoalkyl; and R 2 is hydrogen, nitro, cyano, alkanesulphonyl or aryl-sulphonyl) are made by standard methods. 2 - [(5 - Methylimidazol - 4 - yl)methyl]thioethylamine dihydrochloride and the corresponding sulphoxide are also prepared. Pharmaceutical preparations capable of inhibiting histamine H-2 receptors contain (I) as active ingredient. Administration is preferably orally.n[GB1421999A]
priorityDate 1973-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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