http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-37481-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00 |
| filingDate | 1973-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-37481-L |
| titleOfInvention | 3-formylrifamycin azines |
| abstract | 1392272 Rifamycin derivatives GRUPPO LEPETIT SpA 29 March 1973 [31 May 1972] 15l91/ Heading C2C Derivatives of rifamycin SV having the general formula and 16, 17, 18, 19, 28 and 29 hexahydro and 25-desacetyl derivatives thereof wherein the symbol Rifa represents the rifamycin radical of formula and A represents (1) a direct bond connecting the two nitrogen atoms ; (2) a group wherein y is -CO-, -CNH-, -CS-, -SO 2 -, a divalent, aliphatic, cycloaliphatic, aromatic, araliphatic, or heterocyclic radical; R 2 and R 3 indedendently represent hydrogen, alkyl or taken together represent an aliphatic divalent chain of 1-4 carbon atoms connecting the two terminal nitrogen atoms, or (3) a divalent group wherein X represents a direct bond between the two carbon atoms, a divalent aliphatic, cycloaliphatic, aromatic, or heterocyclic radical, R and R 1 may be independently hydrogen, alkyl, cycloalkyl, aryl, heterocyclic or taken together represent an aliphatic chain of 1 to 8 C atoms connecting the two terminal carbon atoms, may be prepared by reacting 3-formylrifamycin SV or its 25-desacetyl or 16, 17, 18, 19, 28 and 29 hexahydro derivative with a hydrazine compound of the formula H 2 N-A-NH 2 in an inert organic solvent at a temperature ranging from room temperature to the boiling temperature of the solvent. Compounds prepared include 3-formylrifamycin SV azine, 16, 17, 18, 19, 28, 29 - hexahydro - 3 - formylrifamycin SV azine and 1,4-piperazinylidene-bis-(3,3<SP>1</SP>-iminomethyl rifamycin SV). Pharmaceutical compositions having antibacterial and anti-tumour activity comprise the above derivatives of rifamycin SV and a pharmaceutically acceptable carrier.n[GB1392272A] |
| priorityDate | 1972-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 33.