http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-37473-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d757a010abaaa7cd45b5a33e46ca149 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-683 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-08 |
| filingDate | 1973-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-37473-L |
| titleOfInvention | Cyclopentindene derivatives |
| abstract | 1409551 1,2,3,3aα,8,8aα - Hexahydrocyclopent[a]inden-1-yl-amines ALLEN & HANBURYS Ltd 28 March 1973 [14 April 1972] 17222/72 Heading C2C Novel 1,2,3,3aα,8,8aα - hexahydrocyclopent[a]inden-1-yl-amines of the general formula wherein each of R 1 and R 2 a hydrogen atom or a C 1-6 alkyl or arylakyl group or R 1 and R 2 , together with the adjacent carbon atom, form a C 3-6 cycloalkone ring, R 3 is a hydrogen atom or a C 1-6 alkyl group and R 4 is a -NR 5 R 6 group, in which each of R 5 and R 6 is a hydrogen atom, a carbamoyl group, or a C 1-6 alkyl group, optionally substituted by an amino, alkylamino, dialkylamino, hydroxy, aryl or optionally substituted aroyl group, or R 5 and R 6 , together with the adjacent nitrogen atom, form a ring which may additionally contain other heteroatoms, and non-toxic, pharmaceutically acceptable salts and esters thereof are prepared (a) when R 3 is a hydrogen atom, by reductively aminating a ketone of the general formula with a compound of the general formula R 4 H; (b) when R 3 is a hydrogen atom and R 4 is -NH 2 by reducing the oxime of a ketone of the second or third general formula above; (c) when R 3 is a hydrogen atom, by reacting a tosyl ester of the general formula with a compound of the fourth general formula above; (d) when R 5 is a carbamoyl group, by reacting the corresponding compound in which R 5 is a hydrogen atom with sodium cyanate; (e) when each of R 1 , R 2 and R 3 is a hydrogen atom and each of R 5 and R 6 is a methyl group, by reacting the corresponding compound in which each of R 5 and R 6 is a hydrogen atom with formaldehyde and formic acid; (f) when R 3 is a C 1-6 alkyl group, by reacting an imine salt of the general formula wherein Hal is a halogen atom, with a compound of the general formula R 3 Li wherein R 3 is a C 1-6 alkyl group; and (g) when at least one of R 5 and R 6 is an optionally substituted C 1-6 alkyl group, by alkylating (directly or reductively) the corresponding compound in which at least one of R 5 and R 6 is a hydrogen atom; followed optionally by salification or esterification of the product. The oxime starting materials used in process (b) above are prepared by reacting the corresponding 3,8-dihydro- or 3,3a,8,8a-tetrahydrocyclopent[a]inden-1[2H]-one with hydroxylamine hydrochloride. 3,3a,8,8a-Tetrahydrocyclopent[a]inden - 1 [2H] - one is prepared by catalytic hydrogenation of 3,8-dihydrocyclopent[a]- inden - 1[2H] - one. 3,8 - Dihydro - 8,8 - dimethyl - cyclopent[a]inden - 1[2H]one is prepared by reacting 3,8-dihydrocyclopent[a]inden- 1[2H]-one with methyl iodide in the presence of sodium hydride; and the corresponding 8,8-dibenzyl compound is prepared analogously using benzyl bromide. (3,3a,8,8a - Tetrahydrocyclopent[a]inden - 1- [2H]-ylidene) isopropyl methyl ammonium iodide is prepared by reacting 3,3a,8,8a-tetrahydrocyclopent[a]inden-1[2H]-one with isopropylamine and treating the resulting 3,3a,8,8atetrahydro - N - isopropylcyclopent[a]inden- 1[2H]-imine with methyl iodide. 1,2,3,3aα,8,8aα - Hexahydrocyclopent[a]inden- 1#-ol toluene-p-sulphonate ester is prepared by reduction of 3,8-dihydrocyclopent[a]inden-1[2H]- one and reaction of the resulting 1,2,3,3aα,8,8aα- hexahydrocyclopent[a]inden- 1# - ol with p. toluenesulphonyl chloride. Pharmaceutical compositions having analgetic activity comprise, as active ingredient, a 1,2,3,3aα,8,8aα - hexahydrocyclopent[a]inden- 1-yl-amine of the first general formula above or a non-toxic, pharmaceutically acceptable salt or ester thereof, together with an inert pharmaceutical carrier.n[GB1409551A] |
| priorityDate | 1972-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.