http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-37051-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fa68ae66fed2f54717da32e57f7735f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 |
| filingDate | 1972-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-37051-L |
| titleOfInvention | Histidine derivatives |
| abstract | 1374317 Histidine derivative RECKITT & COLMANN PRODUCTS Ltd 28 Dec 1972 [20 Jan 1972] 2695/72 Heading C2C The novel compound, N-(cyclopentylcarbonyl - L - histidyl)pyrrolidine, and pharmaceutically acceptable acid addition salts thereof are prepared by reacting cyclopentanecarboxylic acid or reactive functional derivatives thereof with N-(L-histidyl)pyrrolidine, or by reacting pyrrolidine with N-(cyclopentylcarbonyl)-L-histidine or esters thereof. p-Nitrophenyl cyclopentanecarboxylate is obtained by reacting cyclopentanecarboxylic acid with p-nitrophenol in the presence of N,N<SP>1</SP>- dicyclohexylcarbodiimide. N - (L - Histidyl)pyrrolidine hydrochloride is obtained by hydrolysing N-(t-butoxycarbonyl- L-histidyl)pyrrolidine or the hydrogenolysis of N - (benzyloxycarbonyl - L - histidyl)pyrrolidine, both of which are prepared by reacting pyrrolidine with the appropriate L-histidine derivative. Pharmaceutical compositions contain the above novel compound or therapeutically acceptable acid addition salts thereof in association with pharmaceutically acceptable diluents or carriers. The compound inhibits the action of hypothalamic thyrotropin releasing hormone.n[GB1374317A] |
| priorityDate | 1972-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.