http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-36960-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60 |
| filingDate | 1972-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-36960-L |
| titleOfInvention | Cephalosporin intermediates |
| abstract | 1413289 7 - Imidazolidinyl - 3 - bromomethyl cephalosporamic acid silyl esters BRISTOLMYERS CO 27 Sept 1972 [30 Sept 1971] 44691/72 Heading C3S [Also in Division C2] Novel compounds having the formula wherein Ar is phenyl, 2-thienyl or 3-thienyl and R is hydrogen or an easily hydrolysed ester group such as 2,2,2-trichloro-ethyl or silyl, e.g. trimethylsilyl are prepared by brominating a compound of the formula The bromination may be effected with bromine, an N-bromoamide, e.g. caprolactam, an N- bromoacetamide, an N-bromoimide, e.g. the 1,3 - dibromo - 5,5 - dialkyl hydantoins, N- bromosuccinimide and N-bromophthalimide or 1,3,5 - tribromo - 1,2,4 - triazole; and may be initiated by a free-radical initiator such as azo compounds, e.g. azobisisobutyronitrile, peroxide, e.g. benzoyl peroxide, or by irradiation with ultra violet light, visible light or γ- rays; at a temperature from - 80 to + 150 C. 3-Substituted cephalosporins in particular 7- (D - α - amino - α - phenylacetamido) - 3 - (5- methyl - 1,3,4 - oxadiazol - 2 - ylthiomethyl)- 3-cephem-4-carboxylic acid are prepared from the above compounds by nucleophilic displacement of the 3-bromo atom by a suitable organic group, reduction of the sulphoxide group, and removal of the blocking group from the side chain.n[GB1413289A] |
| priorityDate | 1971-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.