http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-35974-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 1972-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-35974-L |
| titleOfInvention | Esterification of n-blocked amino acids |
| abstract | 1377651 Esters of amino acids GLAXO LABORATORIES Ltd 14 Dec 1971 [12 Jan 1971] 1528/71 Heading C2C The invention comprises (i) a process for esterifying an N-blocked amino acid by reacting said N-blocked acid with a hydrazone of general formula (wherein R<SP>2</SP> is hydrogen or an organic group and R<SP>3</SP> is an organic group or R<SP>2</SP> and R<SP>3</SP> together with the adjacent carbon atom form a cyclic organic group) in the presence of an oxidizing agent to give a compound containing an ester group of formula and (ii) the following novel esters: diphenylmethyl D( - )-phenylglycinate hydrochloride; diphenylmethyl D(- )- N - (2,2,2 - trichloroethoxycarbonyl) - 2 - phenylglycinate; diphenylmethyl 3 - acetoxymethyl - 7# - (2- thienylacetamido)ceph - 3 - em - 4 - carboxylate 1#-oxide; and esters of 2,2-dimethyl-6#-phenylacetamidopenam - 3α - carboxylic acid 1#- oxide in which the esterifying group is 2<SP>1</SP>- methyldiphenylmethyl; 3<SP>1 </SP>- methyldiphenylmethyl; 41 - methyldiphenylmethyl; 4<SP>1</SP>- chlorodiphenylmethyl; α -. (thien - 2 - yl)- benzyl; α - methylbenzyl; fluoren - 9 - yl; fur-2-ylmethyl and cyclohexyl. Suitable oxidizing agents are organic peracids (which may be formed in situ from the organic acid and B 2 O 2 ), peresters, chromium trioxide, t-butylhypochlorite, fremys salt, chloric bromic or iodic acid, permanganic acid, ozone, N 2 O 4 , oxygen, lead tetra-acetate, MnO 2 , silver oxide and ceric salts. The process may be assisted by a catalyst such as iodine, cupric acetate, cobalt naphthenate, a ferroussalt or dibenzoyl peroxide.n[GB1377651A] |
| priorityDate | 1971-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.