http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-35775-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe167f94137cb24a7fea600ce7b108b6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-09 |
| filingDate | 1971-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_085c3c0346642a64abc96e711ecb9972 |
| publicationDate | 1976-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-35775-B1 |
| titleOfInvention | Preparation of 1-alkyl-2-aminomethylpyrrolidines |
| abstract | 1374818 1 - Alkyl - 2 - aminomethylpyrrolidines FRATMANN SA 4 Nov 1971 [10 Nov 1970] 51225/71 Heading C2C 1 - Alkyl - 2 - aminomethylpyrrolidines are prepared by reacting a 1-alkyl-2-pyrrolidine in a solvent, e.g. benzene, toluene or xylene, with phosgene at - 5‹ to + 10‹ C.; reacting the resultant product, optionally after isolation and purification of the same, with an alkali metal alcoholate at 0‹ to -20‹C. and then with nitromethane at room temperature; and finally reducing the resultant nitromethylene group to an aminoethyl group. The 1-alkyl-2-nitromethylenepyrrolidine may also be isolated and purified before the reduction and the latter is preferably carried out (i) by catalytic hydrogenation in an inert solvent, e.g. Pt black, Rh on Al 2 O 3 , Pd on charcoal and Raney Ni in water, methanol, ethanol, isopropanol, butanol, tetrahydrofuran or dioxane or (ii) by hydrogen produced in situ by the reaction of an acid on a metal. In the first step of the process the phosgene may be first dissolved in the solvent and then the solution formed added to the 1- alkyl - 2 - pyrrolidine. The 1 - alkyl - 2- aminomethyl pyrrolidine may be converted to a salt by the addition of an acid, e.g. HCl, HBr, H 2 SO 4 , oxalic acid, tartaric acid, maleic acid or picric acid. Examples of the alkyl group in the product are methyl, ethyl (see example), propyl, isopropyl and isobutyl groups. Reference has been directed by the Comptroller to Specification 1,236,842.n[GB1374818A] |
| priorityDate | 1970-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.