| abstract |
1366661 8 - Cyano - 5 - octanolide; 5 - hydroxy- and 5-oxo-azelaonitrile F HOFFMANNLA ROCHE & CO AG 25 Aug 1971 [26 Aug 1970] 39888/71 Heading C2C The novel compound may be prepared by reacting with one equivalent each of water and a strong acid, e.g. H 2 SO 4 or p-toluene sulphonic acid, in an organic solvent at 20-150‹ C. Compound II may be prepared by reduction of in a non-ketonic solvent using Na borohydride, trimethoxy Na borohydride, LiAl tri-t-butoxy hydride, at 10-50‹ C. Compound III may be prepared by hydrolysis of 2,2-di(3-cyanopropyl)-1,3-dioxolane using HCl or acetic acid in a water miscible organic solvent at- 20‹ to + 50‹ C.n[GB1366661A] |