http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-35369-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-70 |
| filingDate | 1971-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-35369-B1 |
| titleOfInvention | Tetrahydropyridine derivatives and a process for the manufacture thereof |
| abstract | 1338056 Tetrahydropyridine derivatives F HOFFMANN-LA ROCHE & CO AG 16 June 1971 [19 June 1970] 28136/71 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein R<SP>1</SP> is H, alkanoyl, alkylsulphonyl, alkyl, cycloalkyl or cycloalkyl-alkyl, R<SP>2</SP> is H, alkyl, cycloalkyl or cycloalkyl-alkyl, X is O or S, and Y is F, Cl or alkoxy, each of the specified organic radicals containing up to 6 carbon atoms. These compounds may be prepared by (1) condensing together the correspondingly substituted (a) phenoxyethyl or phenylthioethyl compound and phenyltetrahydropyridine, or (b) phenyltetrahydro-1- pyridylethyl compound and p-R<SP>1</SP>R<SP>2</SP>NC 6 H 4 XM (M = alkali metal or Mg-halide); (2) dehydrating the corresponding 4-hydroxypiperidine; (3) treating with mineral acid the corresponding 6-methyl-1,3-oxazine (whereby the oxazine rearranges to the tetrahydropyridine); (4) reducing a corresponding 1-(p-nitrophenoxyethyl- or p-nitrophenylthioethyl)-4-phenyltetrahydropyridine or the 1-(p-aminophenoxyacetyl- or p-aminophenylthioacetyl-), or the 1-(p-nitrophenoxyacetyl- or p - nitrophenylthioacetyl-) analogues; and optionally (5) alkanoylating, alkylsulphonylating, alkylating, cycloalkylating or cycloalkyl-alkylating the amine, or hydrolysing the alkanoylamino compound. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have psychosedative activity.n[GB1338056A] |
| priorityDate | 1970-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.