http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-35284-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate | 1971-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-35284-L |
| titleOfInvention | Quinoline derivatives |
| abstract | 1313963 Quinolyl/quinuclidyl ketones and carbinols; substituted-quinolyl lithium compounds F HOFFMANN-LA ROCHE & CO AG 19 April 1971 [16 March 1970] 24189/71 Headings C2C and C2J The title ketones (VI) and carbinols (I, II): wherein m is 1-or 2, R 1 is H, halogen, OH, CF 3 or C 1-7 alkyl or alkoxy,-or (R 1 ) m is methylenedioxy, and R 2 is vinyl or Et, and their enantiomers, racemates and acid addition salts, are prepared by reacting together the corresponding quinolyl-Li (III) with either an epimeric 2-formyl-5- R 2 -quinuclidine (giving I, II) or an epimeric ester of a 5-R 2 -quinuclidine-2-carboxylic acid (giving VI), and in the latter case optionally reducing VI to give I, II. Compounds III, prepared in examples by reacting a corresponding 4-bromoquinoline (from the 4-hydroxyquinoline with PBr 3 + PoBr 3 ) with LiBu, are (except when R 1 =H) claimed per se. Also described are the optical resolution of XCH 2 CHOHCCl 3 (X=3- ethyl - 4 - pyridyl) and the preparation of YCH 2 CHOHCHCl 2 (Y=3-ethyl- or 3-vinyl-4- piperidyl). Therapeutic compositions for oral, parenteral or rectal administration comprise the above carbinols (I, II), which have antimalarial and antiarrhythmic properties.n[GB1313963A] |
| priorityDate | 1970-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.