http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-35186-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| filingDate | 1971-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-35186-B1 |
| titleOfInvention | Amines and a process for the manufacture thereof |
| abstract | 1334430 Aralkylamines and derivatives F HOFFMANN-LA ROCHE & CO AG 5 May 1971 [6 May 1970] 13220/71 Heading C2C Novel compounds of formula wherein one of the symbols R 1 and R 2 represents a formyl group and the other symbol represents a hydroxy group (the symbols R 1 and R 2 being in the ortho- or para-position to each other), the symbols R 3 and R 4 each represents a hydrogen atom or a lower alkyl group, the symbol R 5 represents a hydrogen atom or a carboxyl or lower alkoxycarbonyl group and the symbol R 6 represents a hydrogen atom or a lower alkanoyl or aroyl group, their optical antipodes and pharmaceutically acceptable salts thereof are prepared by formylation of a compound of formula wherein one of the symbols R 7 and R 8 represents a hydrogen atom and the other symbol represents a hydroxy group or a lower alkoxy group (the symbols R 7 and R 8 being in the ortho- or para-position to each other), or an optical antipode or a salt thereof and converting any lower alkoxy group denoted by R 7 or R 8 in the formylation product into a hydroxy group and, if desired and in any desired sequence, converting a compound of Formula I obtained in which the symbol R 5 represents a lower alkoxycarbonyl group into a compound of Formula I in which the symbol R 5 represents a carboxyl group, esterifying a compound of Formula I in which the symbol R 5 represents a carboxyl group, converting a compound of Formula I in which the symbol R 6 represents a lower alkanoyl or aroyl group into a compound of Formula I in which the symbol R 6 represents a hydrogen atom if desired, optionally with salt formation and/or resolution. Pharmaceutical compositions in conventional forms for enteral or parenteral administration and having hypotensive and appetite inhibiting action comprise an above novel compound or salt and a carrier therefor.n[GB1334430A] |
| priorityDate | 1970-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.