http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-34591-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5712b4838bdb16ebbc41121239e165b9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-55 |
| filingDate | 1970-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-34591-L |
| titleOfInvention | Indolizine derivatives. |
| abstract | 1,268,424. Indolizine derivatives. BEECHAM GROUP Ltd. 18 Sept., 1970 [4 Oct., 1969], No. 48856/69. Heading C2C. The invention comprises compounds of formulae the pharmaceutically acceptable salts and esters of I, and the esters and salts of II, wherein R and R<SP>2</SP> are each C 1-6 alkyl, and R<SP>3</SP> is aryl or C 1-6 alkyl. These compounds are prepared by reacting 2-formylpyridine with Ph 3 P : CRCO 2 Et to give 2-(2-carbethoxyalk-1-enyl)pyridine, hydrogenating this (H 2 /Pd-C) to 2-(2-carbethoxyalkyl)pyridine, reacting with (e.g.) BrCH 2 Ac to give 1-acetonyl-2-(2-carbethoxyalkyl)pyridinium bromide which is treated with a base to give II, esterifying the latter and reacting the ester with a reactive derivative of R<SP>3</SP>CO 2 H, and optionally hydrolysing the ester of I thus obtained. Therapeutic compositions for oral or parenteral administration comprise compounds I (above), and their pharmaceutically acceptable salts and esters, which have analgesic and anti inflammatory activity.n[GB1268424A] |
| priorityDate | 1969-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.