http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-34354-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-207 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-207 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-08 |
| filingDate | 1970-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b03a938d16b55d4c6b96e9cfe386d1bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ff81cbacaff3c47617c0643439103ba |
| publicationDate | 1975-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-34354-B1 |
| titleOfInvention | D-glucofuranose compounds and process for preparing them |
| abstract | 1317781 D-Glucofuranose compounds CIBA GEIGY AG 25 June 1970 [3 July 1969] 30865/70 Heading C2C Novel compounds of Formula I: in which R<SP>1</SP> 1 represents a hydrogen atom or a lower alkyl radical, R<SP>1</SP> 2 represents a hydrogen atom or the acyl radical of an aliphatic carboxylic acid or a salicyloyl or O-lower alkanoylsalicyloyl radical, and each of R<SP>1</SP> 3 and R<SP>1</SP> 5 represents a lower alkyl or lower alkenyl group or a benzyl group optionally substituted by lower alkyl, lower alkoxy or trifluoromethyl groups or halogen atoms, or for a salicyloyl or O-lower alkanoyl-salicyloyl radical, or for an O-benzyl-salicyloyl O-lower alkyl-salicyloyl or halogeno-salicyloyl radical, and R<SP>1</SP> 3 may also represent a hydrogen atom, and R<SP>1</SP> 6 represents a lower alkyl or lower alkenyl group or a phenyl or benzyl group optionally substituted by lower alkyl, lower alkoxy or trifluoromethyl groups or halogen atoms, or for a salicyloyl or O-lower alkanoyl-salicyloyl radical, or for an O-benzylsalicyloyl, O-lower alkyl-salicyloyl or halogenosalicyloyl radical, with the proviso that at least one of R<SP>1</SP> 2 , R<SP>1</SP> 3 , R<SP>1</SP> 5 and R<SP>1</SP> 6 represents a salicyloyl or O-lower alkanoyl-salicyloyl radical, or an O-benzyl-salicyloyl O-lower alkyl-salicyloyl or halogeno-salicyloyl radical, and with the further proviso that at least one of R<SP>1</SP> 1 , R<SP>1</SP> 3 , R<SP>1</SP> 5 and R<SP>1</SP> 6 represents one of the optionally substituted hydrocarbon radicals indicated for these groups, are prepared by reacting a compound of Formula II: in which R 1 <SP>0</SP> represents a lower alkyl radical and R 2 <SP>0</SP> represents a hydrogen atom or the acyl radical of an aliphatic carboxylic acid, or R 1 <SP>0</SP> and R 2 <SP>0</SP> together represent an optionally substituted methylene group -X-, and at least one of R 3 <SP>0</SP>, R 5 <SP>0</SP> and R 6 <SP>0</SP> represents a free or reactive esterified hydroxy group and the others have the meanings of R<SP>1</SP> 3 , R<SP>1</SP> 5 , and R<SP>1</SP> 6 , respectively, with salicylic acid or O-lower alkanoyl salicylic acid or a reactive derivative thereof, and reacting a resulting compound of the Formula I in which R<SP>1</SP> 1 and R<SP>1</SP> 2 have the same meanings as R 1 <SP>0</SP> and R 2 <SP>0</SP> respectively, and R 1 <SP>0</SP> and R 2 <SP>0</SP> together represent an optionally substituted methylene group -X-, with a compound of the formula R<SP>1</SP> 1 -OH in the presence of an acid, and, if desired, reacting a resulting compound of the Formula I, in which R<SP>1</SP> 1 represents a hydrogen atom, with an alcohol of the formula R<SP>1</SP> 1 -OH in the presence of an acid, or converting in a resulting compound of the Formula I, in which R<SP>1</SP> 1 represents a hydrogen atom and R<SP>1</SP> 2 preferably stands for an acyl radical of an aliphatic carboxylic acid, the free hydroxy group in 1-position into an esterified hydroxy group and treating the resulting ester with an alcohol of the formula R<SP>1</SP> 1 -OH, and/or, if desired, reacting a resulting compound of the Formula I in which R<SP>1</SP> 1 represents a lower alkyl radical, with an acid in the presence of water, and, if none of R<SP>1</SP> 1 , R<SP>1</SP> 3 , R<SP>1</SP> 5 and R<SP>1</SP> 6 is an optionally substituted hydrocarbon group as specified above, introducing such a group. A resulting compound I can be converted into a different compound I by usual methods, e.g. etherification, hydrolysis, esterification, hydrogenolysis &c. The preparation of compounds II is also described. Pharmaceutical compositions comprise a compound of Formula I together with a pharmaceutical carrier. The compositions have antiinflammatory and analgesic activity.n[GB1317781A] |
| priorityDate | 1969-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.