http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-32959-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-43 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 |
| filingDate | 1969-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-32959-B1 |
| titleOfInvention | Antibacterial compositions |
| abstract | 1,250,714. Penicillins. BRISTOL-MYERS CO. 17 Jan., 1969 [18 Jan., 1968], No. 2749/ 69. Heading A5B. Antibacterial compositions suitable for reconstitution with water to form suspensions for intramuscular use comprise a particulate alpha-aminobenzylpenicillin trihydrate represented by the formula wherein R 1 , R 2 and R 3 are the same or different and each is hydrogen, nitro, di-C 1-6 - alkylamino, C 1-6 -alkanoylamino, C 1-6 -alkanoyloxy, C 1-6 -alkyl, C 1-6 alkoxy, sulphamyl, chloro, iodo, bromo, fluoro, trifluoromethyl, C 1-6 - alkylthio, C 1-6 -alkylsulphonyl, carbo-C 1-6 -alkoxy, benzyl, phenethyl, cycloheptyl, cyclohexyl or cyclopentyl; in which the particles are coated with a physiologically acceptable hydrophilic surface active agent and a phsysiologically acceptable lipophilic surface active agent. The composition may also contain a physiologically acceptable preservative which may also be coated with the surface active agents. The penicillin is preferably alpha-aminobenzylpenicillin trihydrate, the lipophilic surface active agent may be lecithin, sorbitan monopalmitate, and/or sorbitan trioleate and the hydrophilic surface active agent may be a poly oxyalkylene derivative of sorbitan monopalmitate or sorbitan trioleate. The composition may be prepared by mixing particulate alphaaminobenzylpenicillin trihydrate of formula I having a size less than 100 mesh (U.S. sieve series standard) with an organic solvent (e.g. chloroform, methylene chloride, trichloroethylene, other or petroleum ether) solution of the surface active agents, evaporating the solvent to produce particulate trihydrate coated with a mixture of the surface active agents, and if necessary pulverizing the coated material so that not more than 1% by weight thereof is larger than 200 mesh. The compositions may also contain dodecyl gallate, ascorbic acid (or its Na salt), sodium acetate, NaCl, methylcellulose or polyvinylpyrrolidone.n[GB1250714A] |
| priorityDate | 1968-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.