http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-32859-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-06 |
| filingDate | 1968-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-32859-B1 |
| titleOfInvention | Penicilloic acid derivatives and process for the manufacture thereof |
| abstract | 1,201,977. Penicilloic acid derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 20 Dec., 1968 [4 Jan., 1968], No. 60560/68. Heading C2C. Novel penicilloic acid derivatives of the formula wherein n is 1 to 4, R<SP>1</SP> is hydrogen or C 1 to C 6 acyl, and R is 2-pentenyl; n-pentyl; n heptyl; allylthiomethyl; 5-amino-5-carboxypentyl; benzyl; carboxybenzyl; α-aminobenzyl; phenoxybenzyl; phenbxymethyl; α-phenoxyethyl; α- phenoxypropyl; 2,6-dirnethoxyphenyl; 2-ethoxy-1-naphthyl; 3-carboxy-2-quinoxyalinyl; 5- methyl - 3 - phenyl - 4 - isoxazolyl; 3 - (2 - chlorophenyl) - 5 - methyl - 4 - isoxazolyl; or 3 - (2,6 - dichlorophenyl) - 5 - methyl - 4 - isoxazolyl, and salts thereof, are prepared by reacting a penicillin of formula with a diaminocarboxylic acid derivative of formula R and n being as above and R<SP>2</SP> being C 1 to C 6 acyl or an amino-protecting group, (e.g. tert.-butyloxycarbonyl or benzyloxycarbonyl), splitting off the protecting group if present, and optionally converting the reaction product to a salt. The reaction is performed in aqueous alkaline medium. Pharmaceutical compositions comprise the novel penicilloic acids or their pharmaceutically acceptable salts together with a pharmaceutical carrier. The compositions may be in forms for enteral or parenteral administration and are for counteracting allergic reactions produced by administering penicillins.n[GB1201977A] |
| priorityDate | 1968-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.