abstract |
There is provided novel sulfated α-glycolipid compounds of the formulan n whereinn R is an acyl residue of a fatty acid; R¹ is -(CH=CH) m -(CH₂) n -CH₃; R², R³, R⁴ and R⁶ are independently at least two -SO₃H; R², R³, R⁴ R⁵ and R⁶ each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C₁₋₄ alkyl, trifluoromethyl, hydroxy and C₁₋₄ alkoxy; m is an integer of 0 or 1; n is an integer of from 5 to 14, inclusive; or a non-toxic pharmaceutically acceptable salt, solvate or hydrate thereof which are inhibitors of selectin-mediated cellular adhesion and are useful in the treatment or prevention of inflammatory diseases and other pathological conditions in mammals. |