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filingDate 1991-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1994-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber HU-T65368-A
titleOfInvention Vaccines
abstract A recombinant adenovirus acting as a vector for an antigen-producing gene (e.g. a rabies glycoprotein gene) comprises a CAV-2 strain modified to contain the promoter-gene sequence within the region from the SmaI site close to the end of the inverted terminal repeat up to the promoter for the early region 4 (E4). To assist replication the recombinant virus is transfected into a cell line expressing Ela proteins. The recombinant virus is used for the production of a corresponding vaccine.
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